The End Of Knowledge - Vault 3 - G.TEC BCI & Neurotechnology Spring School 2024 - Day 8

graph LR classDef gtec fill:#f9d4d4, font-weight:bold, font-size:14px: classDef recoverix fill:#d4f9d4, font-weight:bold, font-size:14px: classDef patients fill:#d4d4f9, font-weight:bold, font-size:14px: classDef assessments fill:#f9f9d4, font-weight:bold, font-size:14px: classDef results fill:#f9d4f9, font-weight:bold, font-size:14px: A[Christoph Guger] --> B[G.Tec: Austria-based, worldwide offices 1] A --> C[RecoveriX: EEG, avatar, FES, sessions 5] C --> D[Hebb's plasticity: 'neurons wire together' 7] C --> E[Motivation key, video games engage 28] C --> F[18 hours over 25 sessions 29] A --> G[30,000+ treatments, 15 research projects 2] G --> H[Danut: 64 EEG, hand improvement 6] A --> I[Video: patient regains hand function 3] I --> J[Motor imagery: ERD, electrode placement 4] A --> K[Hairdresser: skills improved, work again 8] K --> L[Hairdresser: own studio after RecoveriX 9] A --> M[79-year-old: hand affected, 25 sessions 10] M --> N[Fugl-Meyer improved, 9-Hole Peg faster 11] M --> O[Video: smooth movements after RecoveriX 12] A --> P[53-year-old: hand impaired, RecoveriX helped 14] P --> Q[9-Hole Peg: 10 min to 2:53 15] A --> R[56-year-old: left affected, Fugl-Meyer improved 20] R --> S[9-Hole Peg: 13 min to 2:53 21] A --> T[54-year-old: left affected, RecoveriX helped 22] T --> U[Fugl-Meyer, sensory function improved long-term 23] A --> V[29 assessments: EEG, sensation, dexterity 17] V --> W[MEG: brain health biomarkers, Halder 18] V --> X[Videos: 9-Hole Peg improves, follow-up 19] A --> Y[Side effects: pain, memory improved 13] A --> Z[BCI accuracy improves, patients motivated 16] A --> AA[Further improvement after treatment ends 24] AA --> AB[Benefits maintained 6 months later 25] A --> AC[RecoveriX: neuroplasticity, 3000 repetitions critical 26] AC --> AD[a, B ERD in both hemispheres 27] A --> AE[Multi-modal assessments prove efficacy long-term 30] class A,B,G gtec; class C,D,E,F,AC,AD recoverix; class I,J,K,L,M,N,O,P,Q,R,S,T,U,Y,Z patients; class V,W,X assessments; class AA,AB,AE results;

Resume:

1.- G.Tec has headquarters in Austria and offices worldwide, treating stroke and MS patients with BCI neurorehabilitation.

2.- Over 30,000 treatments done in Schiedlberg. G.Tec also has 15 research projects using BCI technology.

3.- Video shows a patient regaining hand function after BCI treatment, which the patient is very happy about.

4.- Motor imagery of left or right hand causes ERD over contralateral sensorimotor cortex. Electrode placement is critical.

5.- RecoveriX uses 16 EEG electrodes, avatar instructions, and FES to have patients do 240 motor imaginations per 45-min session.

6.- Historical experiments by Danut used 64 EEG channels to investigate electrode placement. Hand movement improved dramatically.

7.- Hebb's plasticity principle underlies RecoveriX training - "neurons that fire together wire together". 25 sessions recommended.

8.- 38-year-old female stroke patient couldn't work as hairdresser. After 5-6 RecoveriX sessions, fine motor skills greatly improved.

9.- She could return to work as hairdresser and open her own studio after 31 RecoveriX sessions. Life-changing improvement.

10.- 79-year-old male, 4 months post-stroke, right hand affected. 25 RecoveriX sessions greatly improved hand function.

11.- Fugl-Meyer score improved 5 points, 9-Hole Peg Test time reduced from 1 min to 35 sec. Almost normal.

12.- Video shows smooth, natural hand movements after RecoveriX compared to impaired movements before. Dramatic change.

13.- Side effects of RecoveriX include reduced pain, better concentration, memory, bladder control. No negative side effects.

14.- 53-year-old male, 11 months post-stroke, right hand severely impaired (Fugl-Meyer 25 pts). After RecoveriX, moderate impairment (46 pts).

15.- Couldn't do 9-Hole Peg Test for 17 sessions. Then from 10 min to 2:53 min in 7 sessions - 359% improvement.

16.- BCI classification accuracy improves across sessions. Patients very motivated. 99% accuracy in one patient, higher than healthy controls.

17.- G.Tec does 29 assessments to objectively track recovery progress, including EEG, sensation testing, dexterity tests, ADLs, etc.

18.- MEG also used to derive brain health biomarkers. Sebastian Halder to discuss this data later.

19.- Videos show progressive improvement in 9-Hole Peg Test across RecoveriX and 6-month follow-up. 18 hours of training life-changing.

20.- 56-year-old female, 3 years post-stroke, left side affected. Improved from severely to mildly impaired on Fugl-Meyer after RecoveriX.

21.- 9-Hole Peg Test not possible for 17 sessions, then from 13 min to 2:53 at end. Dexterity improved 359% in 5 hours.

22.- 54-year-old female, left side affected 30 years prior. Dexterity, ADLs, tremor, spasticity all improved after RecoveriX.

23.- Fugl-Meyer Upper Extremity improved 20 points from severely to moderately impaired. Sensory function almost normal by 6-month follow-up.

24.- RecoveriX leads to further improvement after formal treatment ends as patients use limbs more in daily life. Brain is healthier.

25.- Treatment benefits maintained long-term as measured 6 months later. Functional gains allow return to work and normal life.

26.- RecoveriX taps into neuroplasticity - surviving neurons make new connections to compensate for damaged areas. 3000 repetitions critical.

27.- Treatment causes a and ß ERD in both lesioned and healthy hemispheres, indicating reactivation of damaged sensorimotor areas.

28.- Motivation is key - patients eager to come to therapy as they see daily improvements. Video games increase engagement.

29.- Effective treatment time is ~18 hours, spread over 25 sessions. This concentrated practice induces lasting neuroplastic changes.

30.- Multi-modal assessments critical to prove efficacy. RecoveriX improves impairment, function, ADLs, quality of life in chronic stroke.

Knowledge Vault built byDavid Vivancos 2024