Knowledge Vault 2/49 - ICLR 2014-2023
Daphne Koller ICLR 2018 - Invited Talk - Fireside Chat with Daphne Koller
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Concept Graph & Resume using Claude 3 Opus | Chat GPT4 | Gemini Adv | Llama 3:

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ICLR 2018] Main --> A[Koller transitioned from ML
research to application. 1] A --> B[Computational pathology: ML
diagnosed cancer better. 2] A --> C[Difficult translating academic
ML without champions. 3] C --> D[Cultural barrier between
ML and life sciences. 4] C --> E[Pharma silos hamper
innovative ML application. 5] Main --> F[Koller's career: maximizing
unique impact. 7] F --> G[Few ML-biology bilinguals:
outsized impact opportunity. 8] Main --> H[Coursera co-founded unexpectedly
after online courses. 9] H --> I[Left Stanford for
Coursera's mission. 10] H --> J[Proud of lives transformed
through education. 11] Main --> K[Faced subtle put-downs,
lack of recognition. 12] K --> L[Speak up about bias,
value impactful work. 13] Main --> M[Learning from small, heterogeneous
scientific datasets. 14] M --> N[Explore domains beyond
common benchmark datasets. 15] Main --> O[Interpretability depends on
dataset and problem. 16] O --> P[Match problem and
approach thoughtfully. 17] O --> Q[Combine knowledge and
data for some problems. 18] Main --> R[Causality crucial for biological,
medical applications. 19] R --> S[ML community underutilized
causal inference approaches. 20] R --> T[Collaboratively design experiments
for ML approaches. 21] Main --> U[High-throughput biology tools
enable ML-scale data. 22] U --> V[Founded company uniting
biology and ML. 23] V --> W[Traditional drug development:
hypothesis-driven, few targets. 24] V --> X[ML could improve clinical
trial success rates. 25] V --> Y[ML identifies participants to
demonstrate efficacy efficiently. 26] V --> Z[Shortening drug development
timelines: major achievement. 27] class A,F koller; class B,C,D,E,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z ml; class G,H,I,J education; class K,L diversity; class F,G,J,L,Z impact; class B,C,D,E,R,S,T,U,V,W,X,Y,Z healthcare;


1.-Daphne Koller has transitioned from focusing on machine learning research to applying ML to create meaningful impact, especially in healthcare.

2.-Her work in computational pathology showed data-driven ML could diagnose breast cancer better than pathologists by analyzing tumor micro-environment.

3.-It was difficult to get companies to translate academic ML research like this into clinical practice without internal champions.

4.-There is a significant cultural barrier between the machine learning and life sciences communities due to different ways of thinking.

5.-Big pharma companies often have silos between scientific experiments and computational analysis that hamper innovative application of ML.

6.-Students interested in applying ML to healthcare should learn the vocabulary of both sides and approach collaborations with an open mind.

7.-Koller tries to guide her career by considering how to maximize her unique impact in leaving the world a better place.

8.-Few people are bilingual in both machine learning and biology/health, presenting an opportunity to have outsized impact.

9.-Koller co-founded Coursera unexpectedly when online courses she helped launch at Stanford gained huge worldwide audiences.

10.-She stayed at Coursera for 5 years, leaving Stanford, to see the company and mission through.

11.-She's most proud of the lives Coursera has transformed by providing access to education that enables people to improve their circumstances.

12.-As a woman in male-dominated fields, Koller has avoided egregious sexual harassment but constantly faced subtle put-downs and lack of recognition.

13.-To improve diversity, people should speak up about biased incidents and the community should value work that makes meaningful societal impact.

14.-Exciting ML research directions include techniques for learning from small, heterogeneous datasets common in scientific applications.

15.-The community would benefit from looking at new problem domains beyond commonly used benchmark datasets.

16.-The need for interpretability in machine learning models depends on the specific dataset and problem.

17.-Deep learning has demonstrated value beyond expectations but is not always the right solution - a thoughtful matching of problem and approach is needed.

18.-Models that combine knowledge with data may be valuable for certain problems rather than purely knowledge-free data-driven approaches.

19.-Causality is very important, especially for biological and medical applications which often involve interventional rather than just associative questions.

20.-The ML community has not devoted enough attention to developing and applying causal inference approaches.

21.-To better apply ML in biomedicine, biologists and machine learning researchers should collaboratively design experiments to enable the ML approaches.

22.-In the last 5 years, high-throughput experimental tools have emerged in biology to generate datasets at a scale useful for ML.

23.-Koller recently launched a company to bring together biologists and ML researchers to collaboratively solve important problems in drug discovery and development.

24.-Traditional drug development is hypothesis-driven, focusing resources on clinical trials of a small number of intuitively chosen therapeutic targets.

25.-Applying ML and high-throughput experiments to broadly explore many therapeutic hypotheses could improve success rates of clinical trials.

26.-While the long timelines of clinical trials can't be eliminated, ML could help identify participants to demonstrate efficacy more efficiently.

27.-Shortening drug development timelines from 15 years to 5-7 years through application of ML would be a major achievement.

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